Portal:Medicine

The Medicine Portal

The color fresco Care of The Sick by Domenico di Bartolo, 1441–1442, depicting the Santa Maria della Scala hospital in Siena, Italy

Medicine is the science and practice of caring for patients, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others.

Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of creativity and skill), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, or an ancient philosopher and physician would apply bloodletting according to the theories of humorism. In recent centuries, since the advent of modern science, most medicine has become a combination of art and science (both basic and applied, under the umbrella of medical science). For example, while stitching technique for sutures is an art learned through practice, knowledge of what happens at the cellular and molecular level in the tissues being stitched arises through science.

Prescientific forms of medicine, now known as traditional medicine or folk medicine, remain commonly used in the absence of scientific medicine and are thus called alternative medicine. Alternative treatments outside of scientific medicine with ethical, safety and efficacy concerns are termed quackery. (Full article...)

Featured articles -

Featured articles are displayed here, which represent some of the best content on English Wikipedia.

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  Scanning electron micrograph of Escherichia coli rods

  
  Bacteria (/bækˈtɪəriə/ ; sg.: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in mutualistic, commensal and parasitic relationships with plants and animals. Most bacteria have not been characterised and there are many species that cannot be grown in the laboratory. The study of bacteria is known as bacteriology, a branch of microbiology.
  
  Like all animals, humans carry vast numbers (approximately 10¹³ to 10¹⁴) of bacteria. Most are in the gut, though there are many on the skin. Most of the bacteria in and on the body are harmless or rendered so by the protective effects of the immune system, and many are beneficial, particularly the ones in the gut. However, several species of bacteria are pathogenic and cause infectious diseases, including cholera, syphilis, anthrax, leprosy, tuberculosis, tetanus and bubonic plague. The most common fatal bacterial diseases are respiratory infections. Antibiotics are used to treat bacterial infections and are also used in farming, making antibiotic resistance a growing problem. Bacteria are important in sewage treatment and the breakdown of oil spills, the production of cheese and yogurt through fermentation, the recovery of gold, palladium, copper and other metals in the mining sector (biomining, bioleaching), as well as in biotechnology, and the manufacture of antibiotics and other chemicals. (Full article...)
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  Sadler c. 1915

  
  William Samuel Sadler (June 24, 1875 – April 26, 1969) was an American surgeon, self-trained psychiatrist, and author who helped publish The Urantia Book. The book is said to have resulted from Sadler's relationship with a man through whom he believed celestial beings spoke at night. It drew a following of people who studied its teachings.
  
  A native of Indiana, Sadler moved to Michigan as a teenager to work at the Battle Creek Sanitarium. There he met the physician and health-food promoter John Harvey Kellogg, co-inventor of corn flakes breakfast cereal, who became his mentor. Sadler married Kellogg's niece, Lena Celestia Kellogg, in 1897. He worked for several Christian organizations and attended medical school, graduating in 1906. Sadler practiced medicine in Chicago with his wife, who was also a physician. He joined several medical associations and taught at the McCormick Theological Seminary. Although he was a committed member of the Seventh-day Adventist Church for almost twenty years, he left the denomination after it disfellowshipped his wife's uncle, John Harvey Kellogg, in 1907. Sadler and his wife became speakers on the Chautauqua adult education circuit in 1907, and he became a highly paid, popular orator. He eventually wrote over 40 books on a variety of medical and spiritual topics advocating a holistic approach to health. Sadler extolled the value of prayer and religion but was skeptical of mediums, assisting debunker Howard Thurston, and embraced the scientific consensus on evolution. (Full article...)
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  SARS-CoV-2, a member of the subfamily Coronavirinae

  
  A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898, more than 11,000 of the millions of virus species have been described in detail. The study of viruses is known as virology, a subspeciality of microbiology.
  
  When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent viral particles, or virions, consisting of (i) genetic material, i.e., long molecules of DNA or RNA that encode the structure of the proteins by which the virus acts; (ii) a protein coat, the capsid, which surrounds and protects the genetic material; and in some cases (iii) an outside envelope of lipids. The shapes of these virus particles range from simple helical and icosahedral forms to more complex structures. Most virus species have virions too small to be seen with an optical microscope and are one-hundredth the size of most bacteria. (Full article...)
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  A chest X-ray showing a tumor in the lung (marked by arrow)

  
  Lung cancer, also known as lung carcinoma, is a malignant tumor that begins in the lung. Lung cancer is caused by genetic damage to the DNA of cells in the airways, often caused by cigarette smoking or inhaling damaging chemicals. Damaged airway cells gain the ability to multiply unchecked, causing the growth of a tumor. Without treatment, tumors spread throughout the lung, damaging lung function. Eventually lung tumors metastasize, spreading to other parts of the body.
  
  Early lung cancer often has no symptoms and can only be detected by medical imaging. As the cancer progresses, most people experience nonspecific respiratory problems: coughing, shortness of breath, or chest pain. Other symptoms depend on the location and size of the tumor. Those suspected of having lung cancer typically undergo a series of imaging tests to determine the location and extent of any tumors. Definitive diagnosis of lung cancer requires a biopsy of the suspected tumor be examined by a pathologist under a microscope. In addition to recognizing cancerous cells, a pathologist can classify the tumor according to the type of cells it originates from. Around 15% of cases are small-cell lung cancer (SCLC), and the remaining 85% (the non-small-cell lung cancers or NSCLC) are adenocarcinomas, squamous-cell carcinomas, and large-cell carcinomas. After diagnosis, further imaging and biopsies are done to determine the cancer's stage based on how far it has spread. (Full article...)
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  CT scan of the brain showing subarachnoid hemorrhage as a white area in the center (marked by the arrow) and stretching into the sulci to either side

  
  Subarachnoid hemorrhage (SAH) is bleeding into the subarachnoid space—the area between the arachnoid membrane and the pia mater surrounding the brain. Symptoms may include a severe headache of rapid onset, vomiting, decreased level of consciousness, fever, weakness, numbness, and sometimes seizures. Neck stiffness or neck pain are also relatively common. In about a quarter of people a small bleed with resolving symptoms occurs within a month of a larger bleed.
  
  
  SAH may occur as a result of a head injury or spontaneously, usually from a ruptured cerebral aneurysm. Risk factors for spontaneous cases include high blood pressure, smoking, family history, alcoholism, and cocaine use. Generally, the diagnosis can be determined by a CT scan of the head if done within six hours of symptom onset. Occasionally, a lumbar puncture is also required. After confirmation further tests are usually performed to determine the underlying cause. (Full article...)
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  A serpin (white) with its 'reactive centre loop' (blue) bound to a protease (grey). Once the protease attempts catalysis it will be irreversibly inhibited. (PDB: 1K9O​)

  
  Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. The acronym serpin was originally coined because the first serpins to be identified act on chymotrypsin-like serine proteases (serine protease inhibitors). They are notable for their unusual mechanism of action, in which they irreversibly inhibit their target protease by undergoing a large conformational change to disrupt the target's active site. This contrasts with the more common competitive mechanism for protease inhibitors that bind to and block access to the protease active site.
  
  Protease inhibition by serpins controls an array of biological processes, including coagulation and inflammation, and consequently these proteins are the target of medical research. Their unique conformational change also makes them of interest to the structural biology and protein folding research communities. The conformational-change mechanism confers certain advantages, but it also has drawbacks: serpins are vulnerable to mutations that can result in serpinopathies such as protein misfolding and the formation of inactive long-chain polymers. Serpin polymerisation not only reduces the amount of active inhibitor, but also leads to accumulation of the polymers, causing cell death and organ failure. (Full article...)
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  β-Hydroxy β-methylbutyric acid (HMB), otherwise known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that is used as a dietary supplement and as an ingredient in certain medical foods that are intended to promote wound healing and provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS. In healthy adults, supplementation with HMB has been shown to increase exercise-induced gains in muscle size, muscle strength, and lean body mass, reduce skeletal muscle damage from exercise, improve aerobic exercise performance, and expedite recovery from exercise. Medical reviews and meta-analyses indicate that HMB supplementation also helps to preserve or increase lean body mass and muscle strength in individuals experiencing age-related muscle loss. HMB produces these effects in part by stimulating the production of proteins and inhibiting the breakdown of proteins in muscle tissue. No adverse effects from long-term use as a dietary supplement in adults have been found.
  
  HMB is sold as a dietary supplement at a cost of about US$30–50 per month when taking 3 grams per day. HMB is also contained in several nutritional products, including certain formulations of Ensure and Juven. HMB is also present in insignificant quantities in certain foods, such as alfalfa, asparagus, avocados, cauliflower, grapefruit, and catfish. (Full article...)
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  Cartoon in Punch, November 1858

  
  In 1858 a batch of sweets in Bradford, England, was accidentally adulterated with poisonous arsenic trioxide. About five pounds (two kilograms) of sweets were sold to the public, leading to around 20 deaths and over 200 people suffering the effects of arsenic poisoning.
  
  The adulteration of food had been practised in Britain since before the Middle Ages, but from 1800, with increasing urbanisation and the rise in shop-purchased food, adulterants became a growing problem. With the cost of sugar high, replacing it with substitutes was common. For the sweets produced in Bradford, the confectioner was supposed to purchase powdered gypsum, but a mistake at the wholesale chemist meant arsenic was purchased instead. (Full article...)
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  Amphetamine (contracted from alpha-methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity; it is also used to treat binge eating disorder in the form of its inactive prodrug lisdexamfetamine. Amphetamine was discovered as a chemical in 1887 by Lazăr Edeleanu, and then as a drug in the late 1920s. It exists as two enantiomers: levoamphetamine and dextroamphetamine. Amphetamine properly refers to a specific chemical, the racemic free base, which is equal parts of the two enantiomers in their pure amine forms. The term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic performance enhancer and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. It is a prescription drug in many countries, and unauthorized possession and distribution of amphetamine are often tightly controlled due to the significant health risks associated with recreational use.
  
  The first amphetamine pharmaceutical was Benzedrine, a brand which was used to treat a variety of conditions. Currently, pharmaceutical amphetamine is prescribed as racemic amphetamine, Adderall, dextroamphetamine, or the inactive prodrug lisdexamfetamine. Amphetamine increases monoamine and excitatory neurotransmission in the brain, with its most pronounced effects targeting the norepinephrine and dopamine neurotransmitter systems. (Full article...)
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  Buruli ulcer lesions. Top-left, an early ulcer. Top-right, a larger ulcer across the lower arm and wrist. Bottom, a large ulcer on the thigh.

  
  Buruli ulcer (/bəˈruːli/) is an infectious disease characterized by the development of painless open wounds. The disease is limited to certain areas of the world, most cases occurring in Sub-Saharan Africa and Australia. The first sign of infection is a small painless nodule or area of swelling, typically on the arms or legs. The nodule grows larger over days to weeks, eventually forming an open ulcer. Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability.
  
  Buruli ulcer is caused by skin infection with bacteria called Mycobacterium ulcerans. The mechanism by which M. ulcerans is transmitted from the environment to humans is not known, but may involve the bite of an aquatic insect or the infection of open wounds. Once in the skin, M. ulcerans grows and releases the toxin mycolactone, which blocks the normal function of cells, resulting in tissue death and immune suppression at the site of the ulcer. (Full article...)
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  Diagram of prostate tumor pressing on urethra

  
  Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder. Abnormal growth of prostate tissue is usually detected through screening tests, typically blood tests that check for prostate-specific antigen (PSA) levels. Those with high levels of PSA in their blood are at increased risk for developing prostate cancer. Diagnosis requires a biopsy of the prostate. If cancer is present, the pathologist assigns a Gleason score, and a higher score represents a more dangerous tumor. Medical imaging is performed to look for cancer that has spread outside the prostate. Based on the Gleason score, PSA levels, and imaging results, a cancer case is assigned a stage 1 to 4. A higher stage signifies a more advanced, more dangerous disease.
  
  Most prostate tumors remain small and cause no health problems. These are managed with active surveillance, monitoring the tumor with regular tests to ensure it has not grown. Tumors more likely to be dangerous can be destroyed with radiation therapy or surgically removed by radical prostatectomy. Those whose cancer spreads beyond the prostate are treated with hormone therapy which reduces levels of the androgens (male sex hormones) that prostate cells need to survive. Eventually cancer cells can grow resistant to this treatment. This most-advanced stage of the disease, called castration-resistant prostate cancer, is treated with continued hormone therapy alongside the chemotherapy drug docetaxel. Some tumors metastasize (spread) to other areas of the body, particularly the bones and lymph nodes. There, tumors cause severe bone pain, leg weakness or paralysis, and eventually death. Prostate cancer prognosis depends on how far the cancer has spread at diagnosis. Most men diagnosed have tumors confined to the prostate; 99% of them survive more than 10 years from their diagnoses. Tumors that have metastasized to distant body sites are most dangerous, with five-year survival rates of 30–40%. (Full article...)
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  Sorrowing Old Man (At Eternity's Gate), an 1890 portrait by Vincent van Gogh

  
  Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, the term was adopted by the American Psychiatric Association for this symptom cluster under mood disorders in the 1980 version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), and has become widely used since. The disorder causes the second-most years lived with disability, after lower back pain.
  
  The diagnosis of major depressive disorder is based on the person's reported experiences, behavior reported by relatives or friends, and a mental status examination. There is no laboratory test for the disorder, but testing may be done to rule out physical conditions that can cause similar symptoms. The most common time of onset is in a person's 20s, with females affected about twice as often as males. The course of the disorder varies widely, from one episode lasting months to a lifelong disorder with recurrent major depressive episodes. (Full article...)
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  The 1966 New York City smog was a major air-pollution episode and environmental disaster, coinciding with that year's Thanksgiving holiday weekend. Smog covered the city and its surrounding area from November 23 to 26, filling the city's air with damaging levels of several toxic pollutants. It was the third major smog in New York City, following events of similar scale in 1953 and 1963.
  
  On November 23, a large mass of stagnant air over the East Coast trapped pollutants in the city's air. For three days, New York City was engulfed in dangerously high levels of carbon monoxide, sulfur dioxide, smoke, and haze. Pockets of air pollution pervaded the greater New York metropolitan area, including parts of New Jersey and Connecticut. By November 25, the smog became severe enough that regional leaders announced a "first-stage alert". During the alert, leaders of local and state governments asked residents and industry to take voluntary steps to minimize emissions. Health officials advised people with respiratory or heart conditions to remain indoors. The city shut off garbage incinerators, requiring massive hauling of garbage to landfills. A cold front dispersed the smog on November 26, and the alert ended. (Full article...)
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  High-resolution computed tomography images of the lower chest in a 16-year-old boy with diffuse panbronchiolitis

  
  Diffuse panbronchiolitis (DPB) is an inflammatory lung disease of unknown cause. It is a severe, progressive form of bronchiolitis, an inflammatory condition of the bronchioles (small air passages in the lungs). The term diffuse signifies that lesions appear throughout both lungs, while panbronchiolitis refers to inflammation found in all layers of the respiratory bronchioles (those involved in gas exchange). DPB causes severe inflammation and nodule-like lesions of terminal bronchioles, chronic sinusitis, and intense coughing with large amounts of sputum production.
  
  The disease is believed to occur when there is susceptibility, or a lack of immune system resistance, to DPB-causing bacteria or viruses, caused by several genes that are found predominantly in individuals of East Asian descent. The highest incidence occurs among Japanese people, followed by Koreans. DPB occurs more often in males and usually begins around age 40. It was recognized as a distinct new disease in the early 1960s and was formally named diffuse panbronchiolitis in 1969. (Full article...)
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  Anti-FGM road sign near Kapchorwa, Uganda, 2004

  
  Female genital mutilation (FGM) (also known as female genital cutting, female genital mutilation/cutting (FGM/C) and female circumcision) is the cutting or removal of some or all of the vulva for non-medical reasons. FGM prevalence varies worldwide, but is majorly present in some countries of Africa, Asia and Middle East, and within their diasporas. As of 2024, UNICEF estimates that worldwide 230 million girls and women (144 million in Africa, 80 million in Asia, 6 million in Middle East, and 1-2 million in other parts of the world) had been subjected to one or more types of FGM.
  
  Typically carried out by a traditional circumciser using a blade, FGM is conducted from days after birth to puberty and beyond. In half of the countries for which national statistics are available, most girls are cut before the age of five. Procedures differ according to the country or ethnic group. They include removal of the clitoral hood (type 1-a) and clitoral glans (1-b); removal of the inner labia (2-a); and removal of the inner and outer labia and closure of the vulva (type 3). In this last procedure, known as infibulation, a small hole is left for the passage of urine and menstrual fluid, the vagina is opened for intercourse and opened further for childbirth. (Full article...)

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Pavlik harness is used to treat hip dysplasia.

Photo credit: User:Londenp

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  Coffin birth, also known as postmortem fetal extrusion, is the expulsion of a nonviable fetus through the vaginal opening of the decomposing body of a deceased pregnant woman due to increasing pressure from intra-abdominal gases. This kind of postmortem delivery occurs very rarely during the decomposition of a body. The practice of chemical preservation, whereby chemical preservatives and disinfectant solutions are pumped into a body to replace natural body fluids (and the bacteria that reside therein), have made the occurrence of "coffin birth" so rare that the topic is rarely mentioned in international medical discourse.
  
  Typically during the decomposition of a human body, naturally occurring bacteria in the organs of the abdominal cavity (such as the stomach and intestines) generate gases as by-products of metabolism, which causes the body to swell. In some cases, the confined pressure of the gases can squeeze the uterus (the womb), even forcing it downward, and it may turn inside-out and be forced out of the body through the vaginal opening (a process called prolapse). If a fetus is contained within the uterus, it could therefore be expelled from the mother's body through the vaginal opening when the uterus turns inside-out, in a process that, to outward appearances, mimics childbirth. The main differences lie in the state of the mother and fetus and the mechanism of delivery: in the event of natural, live childbirth, the mother's contractions thin and widen the cervix to expel the infant from the womb; in a case of coffin birth, built-up gas pressure within the putrefied body of a pregnant woman pushes the dead fetus from the body of the mother. (Full article...)
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  Karyotype of XXXYY syndrome

  
  XXXYY syndrome, also known as 49,XXXYY, is a chromosomal disorder in which a male has three copies of the X chromosome and two copies of the Y chromosome. XXXYY syndrome is exceptionally rare, with only eight recorded cases. Little is known about its presentation, but associated characteristics include intellectual disability, anomalies of the external genitalia, and characteristic physical and facial features. It is not caused by characteristics of the parents, but rather occurs via nondisjunction, a random event in gamete development. The karyotype observed in the syndrome is formally known as 49,XXXYY, which represents the 49 chromosomes observed in the disorder as compared to the 46 in normal human development.
  
  XXXYY syndrome was first recorded in 1963. Its long-term prognosis is poorly understood; while the condition as reported in the medical literature is relatively severe, it is unknown if there are milder cases that have not come to diagnostic attention. (Full article...)
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  Collecting the dead for burial during the Great Plague

  
  
  The Great Plague of London, lasting from 1665 to 1666, was the most recent major epidemic of the bubonic plague to occur in England. It happened within the centuries-long Second Pandemic, a period of intermittent bubonic plague epidemics that originated in Central Asia in 1331 (the first year of the Black Death), and included related diseases such as pneumonic plague and septicemic plague, which lasted until 1750.
  
  The Great Plague killed an estimated 100,000 people—almost a quarter of London's population—in 18 months. The plague was caused by the Yersinia pestis bacterium, which is usually transmitted to a human by the bite of a flea or louse. (Full article...)
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  Martha Maria "Mattie" Hughes Cannon (July 1, 1857 – July 10, 1932) was a British-American politician, physician, Utah women's rights advocate, suffragist, and a polygamous wife engaged in polygyny. Her family immigrated to the United States as converts to the Church of Jesus Christ of Latter-day Saints (LDS Church) and traveled West to settle in the Utah territory with other church members. She started working at the age of fourteen, and at sixteen she enrolled in the University of Deseret (now called the University of Utah), receiving a bachelor's degree in Chemistry. She later attended the University of Michigan and received an M.D.. She became the fourth of six wives in a polygamous marriage to Angus M. Cannon, a prominent Latter-day Saint leader during the anti-polygamy crusade. Cannon exiled herself to Europe so she wouldn't have to testify against her husband and others. Upon returning to Utah, Cannon worked as a doctor and fought for women's rights. She helped put women enfranchisement into Utah's constitution when it was granted statehood in 1896. On November 3, 1896, Cannon became the first female state senator elected in the United States, defeating her own husband, who was also on the ballot. Cannon was the author of Utah sanitation laws and was a founder and member of Utah's first State Board of Health. (Full article...)
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  BGR-34 (Blood Glucose Regulator-34) is an Ayurvedic-derived product that is sold in India as an over-the-counter pill for the management of type 2 diabetes. It was developed in 2015 by two government-owned laboratories and launched commercially in 2016. It has been tested in only one, modest-sized, human trial. The drug has been heavily criticized, and without more clinical trials, its efficacy remains unproven. The manufacturers have refused to acknowledge the claims of inefficacy and other concerns. (Full article...)
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  Constance Virginia Kies (December 13, 1934 – November 30, 1993) was an American nutrition scientist and dietitian. Kies worked as a public school teacher for three years before going against the traditional gender norms of her time and completing an M.S. and Ph.D. from the University of Wisconsin–Madison. Over the duration of her 30-year career at the University of Nebraska–Lincoln, Kies researched nutritional biochemistry. She demonstrated relationships between minerals, proteins, and dietary fiber through pioneering human subject research. Her findings led to advancements in human knowledge of copper and protein metabolism. She was honored with the Borden Award and was a fellow of the American College of Nutrition. Kies was a feminist and a member of the National Organization for Women and the Women's Equity Action League. She died of uterine cancer three months after her diagnosis. (Full article...)
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  Chest X-ray showing a hepatic hydrothorax in a person with cirrhosis

  
  Hepatic hydrothorax is a rare form of pleural effusion that occurs in people with liver cirrhosis. It is defined as an effusion of over 500 mL in people with liver cirrhosis that is not caused by heart, lung, or pleural disease. It is found in 5–10% of people with liver cirrhosis and 2–3% of people with pleural effusions. In cases of decompensated liver cirrhosis, prevalence rises significantly up to 90%. Over 85% of cases occurring on the right, 13% on the left, and 2% on both. Although it is most common in people with severe ascites, it can also occur in people with mild or no ascites. Symptoms are not specific and mostly involve the respiratory system.
  
  The condition is diagnosed based on the existence of liver cirrhosis and fluid build-up in the abdomen (ascites) and analysis of the fluid. The fluid has a low protein content. Mainly, the condition is treated by medical management, such as diet adjustment and usage of diuretics. When the condition does not respond, it is known as refractory hepatic hydrothorax: treatment includes inserting a transjugular intrahepatic portosystemic shunt (TIPS). The only curative treatment is a liver transplant. The prognosis is usually unfavorable, especially in refractory cases, due to the majority of people being unsuitable for transplantation. However, transplantation indicates a favorable prognosis; one case study showed that the condition had no effect on post-transplant outcomes. (Full article...)
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  Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often in the back along with muscle weakness, beginning in the feet and hands, often spreading to the arms and upper body. The symptoms may develop over hours to a few weeks. During the acute phase, the disorder can be life-threatening, with about 15% of people developing weakness of the breathing muscles requiring mechanical ventilation. Some are affected by changes in the function of the autonomic nervous system, which can lead to dangerous abnormalities in heart rate and blood pressure.
  
  
  Although the cause is unknown, the underlying mechanism involves an autoimmune disorder in which the body's immune system mistakenly attacks the peripheral nerves and damages their myelin insulation. Sometimes this immune dysfunction is triggered by an infection or, less commonly, by surgery, and by vaccination. The diagnosis is usually based on the signs and symptoms through the exclusion of alternative causes and supported by tests such as nerve conduction studies and examination of the cerebrospinal fluid. There are a number of subtypes based on the areas of weakness, results of nerve conduction studies, and the presence of certain antibodies. It is classified as an acute polyneuropathy. (Full article...)
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  Dame Mary Ranken, Lady Herring, DBE, CStJ (née Lyle; 31 March 1895 – 26 October 1981) was an Australian medical practitioner and community worker.
  
  A graduate of the University of Melbourne, where she studied medicine and excelled at sports, Mary qualified as a general practitioner in 1921 and became a resident surgeon at Royal Melbourne Hospital. Her work was mainly with poor women, many of whom lived in unsanitary conditions and had inadequate diets. The social mores of the time often kept young women ignorant of matters dealing with sex and pregnancy. She recognised that pregnant women in particular needed more information about what was happening to them, and provided information on birth control at a time when many doctors and a large segment of the community were opposed to it. "She broke taboos", Della Hilton later wrote, and "made forbidden subjects not only matters for discussion, but for action". (Full article...)
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  Typical purpura on lower legs and buttocks

  
  Henoch–Schönlein purpura (HSP), also known as IgA vasculitis, is a disease of the skin, mucous membranes, and sometimes other organs that most commonly affects children. In the skin, the disease causes palpable purpura (small, raised areas of bleeding underneath the skin), often with joint pain and abdominal pain. With kidney involvement, there may be a loss of small amounts of blood and protein in the urine (hematuria and proteinuria), but this usually goes unnoticed; in a small proportion of cases, the kidney involvement proceeds to chronic kidney disease. HSP is often preceded by an infection, such as a throat infection.
  
  HSP is a systemic vasculitis (inflammation of blood vessels) and is characterized by deposition of immune complexes containing the antibody immunoglobulin A (IgA); the exact cause for this phenomenon is unknown. In children, it usually resolves within several weeks and requires no treatment apart from symptom control but may relapse in a third of cases and cause irreversible kidney damage in about one in a hundred cases. In adults, the prognosis is different from in children. The average duration of cutaneous lesions is 27.9 months. For many, it tends to be relapsing–remitting over a long period of time, rather than self-limiting and there tend to be more complications. (Full article...)
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  Vera Gedroits with patients circa 1915

  
  Princess Vera Ignatievna Gedroits (Russian: Ве́ра Игна́тьевна Гедро́йц listen; 7 April 1870 O.S./19 April 1870 N.S. – March 1932, literary pen name Sergei Gedroits) was a Russian doctor of medicine and author. She was the first woman military surgeon in Russia, the first woman professor of surgery, and the first woman to serve as a physician to the Imperial Court of Russia.
  
  Following her involvement in a student movement, Gedroits was unable to complete her studies in Russia, and despite being openly lesbian, entered into a marriage of convenience, which allowed her to obtain a passport in another name and leave the country. In Switzerland, she enrolled in the medical courses of César Roux and graduated in 1898, working as Roux’s assistant, but returned to Russia because of illnesses in her family. (Full article...)
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  A freshly inserted lumbar epidural catheter. The site has been prepared with tincture of iodine, and the dressing has not yet been applied. Depth markings may be seen along the shaft of the catheter.

  
  Epidural administration (from Ancient Greek ἐπί, "upon" + dura mater) is a method of medication administration in which a medicine is injected into the epidural space around the spinal cord. The epidural route is used by physicians and nurse anesthetists to administer local anesthetic agents, analgesics, diagnostic medicines such as radiocontrast agents, and other medicines such as glucocorticoids. Epidural administration involves the placement of a catheter into the epidural space, which may remain in place for the duration of the treatment. The technique of intentional epidural administration of medication was first described in 1921 by Spanish military surgeon Fidel Pagés.
  
  Epidural anaesthesia causes a loss of sensation, including pain, by blocking the transmission of signals through nerve fibres in or near the spinal cord. For this reason, epidurals are commonly used for pain control during childbirth and surgery, for which the technique is considered safe and effective, and is considered more effective and safer than giving pain medication by mouth or through an intravenous line. An epidural injection may also be used to administer steroids for the treatment of inflammatory conditions of the spinal cord. It is not recommended for people with severe bleeding disorders, low platelet counts, or infections near the intended injection site. Severe complications from epidural administration are rare, but can include problems resulting from improper administration, as well as adverse effects from medicine. The most common complications of epidural injections include bleeding problems, headaches, and inadequate pain control. Epidural analgesia during childbirth may also impact the mother's ability to move during labor. Very large doses of anesthetics or analgesics may result in respiratory depression. (Full article...)
• 
  
  

  

  Melioidosis abscess on the abdomen

  
  Melioidosis is an infectious disease caused by a gram-negative bacterium called Burkholderia pseudomallei. Most people exposed to B. pseudomallei experience no symptoms; however, those who do experience symptoms have signs and symptoms that range from mild, such as fever and skin changes, to severe with pneumonia, abscesses, and septic shock that could cause death. Approximately 10% of people with melioidosis develop symptoms that last longer than two months, termed "chronic melioidosis".
  
  Humans are infected with B. pseudomallei by contact with contaminated soil or water. The bacteria enter the body through wounds, inhalation, or ingestion. Person-to-person or animal-to-human transmission is extremely rare. The infection is constantly present in Southeast Asia particularly in northeast Thailand and northern Australia. In temperate countries such as Europe and the United States, melioidosis cases are usually imported from countries where melioidosis is endemic. The signs and symptoms of melioidosis resemble tuberculosis and misdiagnosis is common. Diagnosis is usually confirmed by the growth of B. pseudomallei from an infected person's blood or other bodily fluid such as pus, sputum, and urine. Those with melioidosis are treated first with an "intensive phase" course of intravenous antibiotics (most commonly ceftazidime) followed by a several-month treatment course of co-trimoxazole. In countries with an advanced healthcare system, approximately 10% of people with melioidosis die from the disease. In less developed countries, the death rate could reach 40%. (Full article...)
• 
  
  

  

  Three-quarter facial view, first-generation patient showing slight prognathism and low set ears

  
  Noonan syndrome with multiple lentigines (NSML) which is part of a group called Ras/MAPK pathway syndromes, is a rare autosomal dominant, multisystem disease caused by a mutation in the protein tyrosine phosphatase, non-receptor type 11 gene (PTPN11). The disease is a complex of features, mostly involving the skin, skeletal and cardiovascular systems, which may or may not be present in all patients. The nature of how the mutation causes each of the condition's symptoms is not well known; however, research is ongoing. It is a RASopathy.
  
  Noonan syndrome with multiple lentigines is caused by a different missense mutation of the same gene. Noonan syndrome is fairly common (1:1,000 to 1:2,500 live births), and neurofibromatosis 1 (which was once thought to be related to NSML) is also common (1:3500); however, no epidemiological data exists for NSML. (Full article...)
• 
  
  

  

  A glass of cow's milk

  
  Milk allergy is an adverse immune reaction to one or more proteins in cow's milk. Symptoms may take hours to days to manifest, with symptoms including atopic dermatitis, inflammation of the esophagus, enteropathy involving the small intestine and proctocolitis involving the rectum and colon. However, rapid anaphylaxis is possible, a potentially life-threatening condition that requires treatment with epinephrine, among other measures.
  
  
  In the United States, 90% of allergic responses to foods are caused by eight foods, and cow's milk is the most common. Recognition that a small number of foods are responsible for the majority of food allergies has led to requirements to prominently list these common allergens, including dairy, on food labels. One function of the immune system is to defend against infections by recognizing foreign proteins, but it should not overreact to food proteins. Heating milk proteins can cause them to become denatured, losing their three-dimensional configuration and allergenicity, so baked goods containing dairy products may be tolerated while fresh milk triggers an allergic reaction. (Full article...)

Did you know –

• ... that the most common cause of acute coronary syndrome is disruption of atherosclerotic plaque in a coronary artery?

• ... that the polymeal is a diet-based approach to combating heart disease, proposed in December 2004 by Oscar Franco?
• ... that a mammotome is a device that uses a computer-guided probe to perform breast biopsies, and that it can be conducted on an outpatient basis under local anaesthetic?

General images –

The following are images from various Medicine-related articles on Wikipedia.

• 
  Smallpox vaccination in Niger, 1969. A decade later, this was the first infectious disease to be eradicated. (from History of medicine)
• 
  18th-century medical remedies collected by a British Gentry family (from History of medicine)
• 
  Statue of Robert Koch, father of medical bacteriology, at Robert-Koch-Platz (Robert Koch square) in Berlin (from History of medicine)
• 
  Total healthcare cost per person. Public and private spending. US dollars PPP. For example: $6,319 for Canada in 2022. $12,555 for the US in 2022. (from Health care)
• 
  An American billing clerk preparing a detailed invoice. (1992) (from Medical billing)
• 
  AMA Code of Medical Ethics (from Medical ethics)
• 
  Guy's Hospital in 1820 (from History of medicine)
• 
  The plinthios brochos as described by Greek physician Heraklas, a sling for binding a fractured jaw. These writings were preserved in one of Oribasius' collections. (from History of medicine)
• 
  Patient, Surrey County Lunatic Asylum, c. 1850–58. The asylum population in England and Wales rose from 1,027 in 1827 to 74,004 in 1900. (from History of medicine)
• 
  Ethical prayer for medical wisdom by Dr Edmond Fernandes (from Medical ethics)
• 
  Hippocrates (c. 460–370 BCE). Known as the "father of medicine". (from History of medicine)
• 
  Primary care may be provided in community health centers. (from Health care)
• 
  Health spending by country. Percent of GDP (Gross domestic product). For example: 11.2% for Canada in 2022. 16.6% for the United States in 2022. (from Health care)
• 
  Medicine during the First World War - Medical Transport. (from History of medicine)
• 
  Jackson Memorial Hospital in Miami, the primary teaching hospital of the University of Miami's Miller School of Medicine and the largest hospital in the United States with 1,547 beds (from Health care)
• 
  The numbers of Americans lacking health insurance and the uninsured rate from 1987 to 2008 (from Health insurance)
• 
  Global concentrations of health care resources, as depicted by the number of physicians per 10,000 individuals, by country. Data is sourced from a World Health Statistics 2010, a WHO report. (from Health care)
• 
  The Quaker-run York Retreat, founded in 1796, gained international prominence as a centre for moral treatment and a model of asylum reform following the publication of Samuel Tuke's Description of the Retreat (1813). (from History of medicine)
• 
  A 12th-century Byzantine manuscript of the Hippocratic Oath (from Medical ethics)
• 
  A 12th-century manuscript of the Hippocratic Oath in Greek, one of the most famous aspects of classical medicine that carried into later eras (from History of medicine)
• 
  Emil Kraepelin (1856–1926), the founder of modern scientific psychiatry, psychopharmacology and psychiatric genetics. (from History of medicine)
• 
  Hospital train "Therapist Matvei Mudrov" in Khabarovsk, Russia (from Health care)
• 
  Yarrow, a medicinal plant found in human-occupied caves in the Upper Palaeolithic period. (from History of medicine)
• 
  A Ukrainian monument to the HIV pandemic. (from History of medicine)
• 
  A doctor checks a patient's pulse in Meiji-era Japan. (from History of medicine)
• 
  National Hospital for Neurology and Neurosurgery in London, United Kingdom is a specialist neurological hospital. (from Health care)
• 
  A cochlear implant is a common kind of neural prosthesis, a device replacing part of the human nervous system. (from History of medicine)
• 
  healthcare expenditure in Japan by age group (from Health insurance)
• 
  A cuneiform terracotta tablet describing a medicinal recipe for poisoning (c. 18th century BCE). Discovered in Nippur, Iraq.
• 
  Infographic showing how healthcare data flows within the billing process (from Medical billing)
• 
  "More Doctors Smoke Camels than Any Other Cigarette" advertisement for Camel cigarettes in the 1940s (from Medical ethics)
• 
  Depiction of smallpox in Franciscan Bernardino de Sahagún's history of the conquest of Mexico, Book XII of the Florentine Codex, from the defeated Aztecs' point of view (from History of medicine)
• 
  Sometimes traditional medicines include parts of endangered species, such as the slow loris in Southeast Asia. (from Traditional medicine)
• 
  Medical personnel place sterilized covers on the arms of the daVinci Xi surgical system, a minimally-invasive robotic surgery system, at the William Beaumont Army Medical Center. (from History of medicine)
• 
  Mandrake (written 'ΜΑΝΔΡΑΓΟΡΑ' in Greek capitals). Naples Dioscurides, 7th century (from History of medicine)
• 
  Health Expenditure per capita (in PPP-adjusted US$) among several OECD member nations. Data source: OECD's iLibrary (from Health insurance)
• 
  Replica of Antonie van Leeuwenhoek's microscope of the 1670s (from History of medicine)
• 
  American combat surgery during the Pacific War, 1943 (from History of medicine)
• 
  Sketch of Muslim physician Muhammad ibn Zakariya al-Razi (from History of medicine)
• 
  "Diagram of the causes of mortality in the army in the East" by Florence Nightingale. (from History of medicine)
• 
  Life Expectancy of the total population at birth among several OECD member nations. Data source: OECD's iLibrary (from Health insurance)
• 
  Magical stela or cippus of Horus inscribed with healing encantations (c. 332 to 280 BCE). (from History of medicine)
• 
  American Civil War hospital at Gettysburg, 1863 (from History of medicine)
• 
  Mexico City epidemic of 1737, with elites calling on the Virgin of Guadalupe (from History of medicine)
• 
  Galen (129–216 CE), known for his wide insights into anatomy. (from History of medicine)
• 
  Botánicas such as this one in Jamaica Plain, Boston, cater to the Latino community and sell folk medicine alongside statues of saints, candles decorated with prayers, lucky bamboo, and other items. (from Traditional medicine)
• 
  The Edwin Smith Surgical Papyrus, written in the 17th century BCE, contains the earliest recorded reference to the brain. New York Academy of Medicine. (from History of medicine)
• 
  A Neo-Assyrian cuneiform tablet fragment describing medical text (c. 9th to 7th century BCE). (from History of medicine)
• 
  Taoist symbol of Yin and Yang (from Medical ethics)
• 
  Seven named physicians and botanists of the Classical world from Vienna Dioscurides. Clockwise from top center: Galen, Dioscorides, Nicander, Rufus of Ephesus, Andreas of Carystus, Apollonius Mus or of Pergamon, Crateuas (from History of medicine)
• 
  Zhang Zhongjing – a Chinese pharmacologist, physician, inventor, and writer of the Eastern Han dynasty. (from History of medicine)
• 
  Life expectancy vs healthcare spending of rich OECD countries. US average of $10,447 in 2018. (from Health care)
• 
  COVID-19 swab testing in Rwanda (2021). (from History of medicine)
• 
  Traditional medicine in a market in Antananarivo, Madagascar (from Traditional medicine)
• 
  Most countries have seen a tremendous increase in life expectancy since 1945. However, in southern Africa, the HIV epidemic beginning around 1990 has eroded national health. (from History of medicine)
• 
  The emergency room is often a frontline venue for the delivery of primary medical care. (from Health care)
• 
  Charite in Berlin (from History of medicine)
• 
  Louis Pasteur experimenting on bacteria, c. 1870 (from History of medicine)
• 
  Curandera performing a limpieza in Cuenca, Ecuador (from Traditional medicine)

More Did you know (auto generated)

• ... that fourteenth-century Buddhist monk Tuệ Tĩnh is referred to as a founding father of traditional Vietnamese medicine?
• ... that Constance Fozzard was told during her surgical training that women with children could not become consultants?
• ... that the Noongar used the Eucalyptus wandoo tree as a medicine and ointment?
• ... that Margaret C. Roberts was encouraged to study medicine by LDS Church leader Brigham Young to reduce mortality rates during childbirth?
• ... that Indian gynaecologist and reproductive medicine pioneer Baidyanath Chakrabarty, who performed over 4,000 IVF procedures, was a cricket fan who thought Virat Kohli and Ashwin were "such good boys"?
• ... that the Anglo-Saxons may have used a mixture of garlic, another Allium, wine, and bovine bile as an eye medicine?

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